The active ingredient in Appesat has been developed to be resistant to stomach acid and remain active for many hours. Taken before food, it works by stimulating hunger 'sensors' in the stomach wall, which then send a signal to the brain informing it that the stomach is full¹. Doctors believe that feeling full (satiation) is an essential factor in any diet for successful weight reduction. Because Appesat is active in your stomach before, during and after you eat it significantly increases the number of 'stomach full' messages your brain receives – allowing you to feel full for much longer.