Product Details
Malarone Paediatric Tablet (Atovaquone Proguanil)
Malarone Paediatric belongs to a group of medicines called Malarone Paediatric
antimalarials. Each tablet contains two active ingredients, atovaquone and proguanil hydrochloride. These are both medicines that are active against the parasite that causes malaria. Malarone Paed tablets contain 62.5mg atovaquone and 25mg proguanil.
Malaria is a potentially fatal disease caused by various types of parasites known as Plasmodium. Plasmodium are carried by mosquitoes and are injected into the bloodstream during a bite from an infected mosquito. Once inside the body the parasite reproduces, resulting in the disease.
Proguanil works by stopping the parasite from reproducing once it is in the bloodstream. It does this by blocking the action of a compound that is found in the Plasmodium parasite. This compound is an enzyme called dihydrofolate reductase, and is involved in the reproduction of the parasite.
Dihydrofolate reductase normally converts folic acid into folinic acid in the parasite, which is a step essential for the parasite to produce new genetic material (DNA). New DNA is necessary for the parasite to reproduce. By blocking it's production, proguanil prevents malarial parasites in the blood from reproducing and increasing in number.
Atovaquone also works by interfering with the production of substances needed by the malarial parasites to reproduce. It works in a slightly different way, however, so these two medicines work in combination against the Plasmodium parasite.
Proguanil with atovaquone is used to prevent malaria caused by a type of Plasmodium called Plasmodium falciparum. This parasite causes the most serious form of malaria (malignant malaria). Proguanil with atovaquone may be particularly useful for preventing malaria in travellers to areas where this parasite is known to be resistant to other antimalarial medicines, such as chloroquine. To prevent malaria, this medicine is taken every day, starting 24 to 48 hours before entering the malarious region. It should be taken throughout the stay, and continued for a week after leaving the malarious area.
Higher doses of proguanil and atovaquone are also used to treat uncomplicated malaria caused by infection with the Plasmodium falciparum parasite. However, this combination of medicines has not been evaluated for the treatment of more complicated or severe malaria affecting the brain, lungs or kidneys.
Warnings
Malarone Paediatric Tablet (Atovaquone Proguanil)
You should carefully read all product packaging and labels prior to use
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